How To Deal With Lots of Detail

This drawing with all the teeth and wrinkles looks complicated.
It's easier to see if you break it down first into it's largest major shapes.
See that? Much easier to deal with
If you are doing layouts or animation of successful poses with this much detail, it's best to do each pose with the simpler shapes first. Then after all the poses move nicely from pose to pose, you can add in the detail after. -***Wrapping the details around the larger forms

like individual teeth within the larger blocks of teeth.

Make sense?